Both TAE running buffer and TBE running buffer are two most commonly used running buffers for nucleic acid electrophoresis. However, they are quite different in nature, have some useful features and also some disadvantages. You can maximize your results by choosing an electrophoresis buffer that is most compatible for your application. The following table lists their properties, and advantages and disadvantages, and also provides explanation for their peculiar behaviour.

The table above is cited from: https://www.laboratorynotes.com/comparison-of-tae-and-tbe-electrophoresis-buffers/

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